Understanding nucleic acids using synthetic chemistry.

  title={Understanding nucleic acids using synthetic chemistry.},
  author={Steven A. Benner},
  journal={Accounts of chemical research},
  volume={37 10},
This Account describes work done in these laboratories that has used synthetic, physical organic, and biological chemistry to understand the roles played by the nucleobases, sugars, and phosphates of DNA in the molecular recognition processes central to genetics. The number of nucleobases has been increased from 4 to 12, generating an artificially expanded genetic information system. This system is used today in the clinic to monitor the levels of HIV and hepatitis C viruses in patients… CONTINUE READING