Understanding nuclear receptors using computational methods.

  title={Understanding nuclear receptors using computational methods.},
  author={Ni Ai and Matthew D. Krasowski and William J. Welsh and Sean Ekins},
  journal={Drug discovery today},
  volume={14 9-10},
Nuclear receptors (NRs) are important targets for therapeutic drugs. NRs regulate transcriptional activities through binding to ligands and interacting with several regulating proteins. Computational methods can provide insights into essential ligand-receptor and protein-protein interactions. These in turn have facilitated the discovery of novel agonists and antagonists with high affinity and specificity as well as have aided in the prediction of toxic side effects of drugs by identifying… CONTINUE READING


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Activated PXR is a target for ketoconazole and its analogs

  • H Wang
  • Clin. Cancer Res
  • 2007
Highly Influential
5 Excerpts

Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

  • Y Xue
  • Bioorg. Med
  • 2007
Highly Influential
3 Excerpts

Evolution of the bile salt nuclear receptor FXR in vertebrates

  • Reschly, E.J
  • J. Lipid Res
  • 2008

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