Understanding morphogenetic growth control — lessons from flies

  title={Understanding morphogenetic growth control — lessons from flies},
  author={Ortrud Wartlick and Peer Mumcu and Frank J{\"u}licher and Marcos Gonzalez-Gaitan},
  journal={Nature Reviews Molecular Cell Biology},
Morphogens are secreted signalling molecules that control the patterning and growth of developing organs. How morphogens regulate patterning is fairly well understood; however, how they control growth is less clear. Four principal models have been proposed to explain how the morphogenetic protein Decapentaplegic (DPP) controls the growth of the wing imaginal disc in the fly. Recent studies in this model system have provided a wealth of experimental data on growth and DPP gradient properties, as… CONTINUE READING


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