Understanding modern-day vaccines: what you need to know

@article{Vetter2018UnderstandingMV,
  title={Understanding modern-day vaccines: what you need to know},
  author={Volker Vetter and G{\"u}lhan Denizer and Leonard R Friedland and Jyothsna Krishnan and Marla Shapiro},
  journal={Annals of Medicine},
  year={2018},
  volume={50},
  pages={110 - 120}
}
Abstract Vaccines are considered to be one of the greatest public health achievements of the last century. Depending on the biology of the infection, the disease to be prevented, and the targeted population, a vaccine may require the induction of different adaptive immune mechanisms to be effective. Understanding the basic concepts of different vaccines is therefore crucial to understand their mode of action, benefits, risks, and their potential real-life impact on protection. This review aims… Expand
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References

SHOWING 1-10 OF 76 REFERENCES
Vaccines for the 21st century
TLDR
The state of the art of recent clinical trials of vaccines for major unmet medical needs such as HIV, malaria, TB, and cancer are reviewed and the innovative technologies currently used in vaccine research and development including adjuvants, vectors, nucleic acid vaccines, and structure‐based antigen design are described. Expand
Vaccine Adjuvants: from 1920 to 2015 and Beyond
TLDR
Adjuvants are the most advanced new technology in the search for new vaccines against challenging pathogens and for vulnerable populations that respond poorly to traditional vaccines. Expand
Vaccine development: From concept to early clinical testing.
TLDR
Any new vaccine development is greatly enhanced by, and requires integration of information concerning, pathogen life-cycle & epidemiology, which guides identification and selection of antigen and the specific immune response required for protection. Expand
DNA vaccines: roles against diseases.
TLDR
DNA vaccines against cancer, tuberculosis, Edwardsiella tarda, HIV, anthrax, influenza, malaria, dengue, typhoid and other diseases were explored and advantages and disadvantages have been explained. Expand
Vaccine impact: Benefits for human health.
Unlike most drugs, whose benefit is restricted to the individual who takes the drug, prophylactic vaccines have the potential for far-reaching effects that encompass health service utilisation,Expand
Vaccines, new opportunities for a new society
TLDR
Overall, vaccines have done and continue to do an excellent job in eliminating or reducing the impact of childhood diseases and have the potential to make an enormous contribution to the health of modern society by preventing and treating not only communicable diseases in all ages, but also noncommunicable diseases such as cancer and neurodegenerative disorders. Expand
Vaccine immunology
TLDR
A review of immunology is provided to enhance understanding of vaccine efficacy and use, and elaborates on the immune response to vaccination. Expand
Current and next generation influenza vaccines: Formulation and production strategies.
TLDR
The next generation of influenza vaccines is addressed, which hopefully will bring cross-reactive influenza vaccines, and developments indicate that an exciting future lies ahead in the influenza vaccine field. Expand
Vector-based genetically modified vaccines: Exploiting Jenner’s legacy
TLDR
Results of this study revealed that vector-based vaccines comprise a significant part of all GM vaccines in the pipeline, and highlights that poxviruses and adenoviruses are among the most prominent vectors in GM vaccine development. Expand
Developing vaccines in the era of genomics: a decade of reverse vaccinology.
  • K. Seib, X. Zhao, R. Rappuoli
  • Biology, Medicine
  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2012
TLDR
Genomics has catalysed a shift in vaccine development towards sequence-based 'Reverse Vaccinology' approaches, which use high-throughput in silico screening of the entire genome of a pathogen to identify genes that encode proteins with the attributes of good vaccine targets. Expand
...
1
2
3
4
5
...