Understanding microtubule dynamics for improved cancer therapy

  title={Understanding microtubule dynamics for improved cancer therapy},
  author={St{\'e}phane Honor{\'e} and Eddy Pasquier and Diane Braguer},
  journal={Cellular and Molecular Life Sciences CMLS},
Microtubules (MTs), key components of the cytoskeleton, are dynamic polymers of tubulin that form a well-organized network of polarized tube filaments. MT dynamics are highly regulated both spacially and temporally by several MT-related proteins, themselves regulated by several kinases and phosphatases via signaling cascades, and also by coordinated interactions with actin cytoskeleton and adhesion sites. Regulation of MT dynamics is crucial for mitosis, cell migration, cell signaling and… CONTINUE READING