Understanding memory through hippocampal remapping

@article{Colgin2008UnderstandingMT,
  title={Understanding memory through hippocampal remapping},
  author={Laura Lee Colgin and Edvard I. Moser and May-Britt Moser},
  journal={Trends in Neurosciences},
  year={2008},
  volume={31},
  pages={469-477}
}
Memory interference is a common cause of forgetting. Interference is a byproduct of the need to balance the formation of well-differentiated representations against the ability to retrieve memories from cues that are not identical to the original experience. How the brain accomplishes this has remained elusive. Here we review how insights can be gained from studies of an apparently unrelated phenomenon in the rodent brain--remapping in hippocampal place cells. Remapping refers to the formation… Expand
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It is shown that activity patterns in human CA3/dentate gyrus exhibit an abrupt, temporally-specific decorrelation of highly similar memory representations that is precisely coupled with behavioral expressions of successful learning, establishing a critical link between hippocampal remapping and episodic memory interference and providing insight into why remapping occurs. Expand
Abrupt remapping in human CA3/dentate gyrus signals resolution of memory interference
TLDR
It is shown that activity patterns in human CA3/dentate gyrus exhibit an abrupt, temporally-specific decorrelation of highly similar memory representations that is precisely coupled with behavioral expressions of successful learning, establishing a critical link between hippocampal remapping and episodic memory interference and providing novel insight into why remapping occurs. Expand
Abrupt remapping in human CA3/dentate gyrus signals resolution of memory interference
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