Understanding local electrophilicity/nucleophilicity activation through a single reactivity difference index.

@article{Chattaraj2012UnderstandingLE,
  title={Understanding local electrophilicity/nucleophilicity activation through a single reactivity difference index.},
  author={Pratim Kumar Chattaraj and Soma Duley and Luis R. Domingo},
  journal={Organic & biomolecular chemistry},
  year={2012},
  volume={10 14},
  pages={2855-61}
}
A local reactivity difference index R(k) is shown to be able to predict the local electrophilic and/or nucleophilic activation within an organic molecule. Together with the electrophilic and/or nucleophilic behavior of the center k given by the sign, the magnitude of the R(k) index accounts for the extent of the electronic activation, a behavior that allows for the use of the R(k) index as a measure of the molecular reactivity especially in polar processes.