Understanding ligand binding effects on the conformation of estrogen receptor alpha-DNA complexes: a combinational quartz crystal microbalance with dissipation and surface plasmon resonance study.

@article{Peh2007UnderstandingLB,
  title={Understanding ligand binding effects on the conformation of estrogen receptor alpha-DNA complexes: a combinational quartz crystal microbalance with dissipation and surface plasmon resonance study.},
  author={Wendy Y X Peh and E. Reimhult and Huey Fang Teh and J. Thomsen and X. Su},
  journal={Biophysical journal},
  year={2007},
  volume={92 12},
  pages={
          4415-23
        }
}
  • Wendy Y X Peh, E. Reimhult, +2 authors X. Su
  • Published 2007
  • Chemistry, Medicine
  • Biophysical journal
  • Estrogen receptors are ligand-activated transcription factors that regulate gene expression by binding to specific DNA sequences. To date, the effect of ligands on the conformation of estrogen receptor alpha (ERalpha)-DNA complex remains a poorly understood issue. In our study, we are introducing the quartz crystal microbalance with dissipation monitoring (QCM-D) as a new alternative to study the conformational differences in protein-DNA complexes. Specifically, we have used QCM-D, in… CONTINUE READING
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