Understanding human disease mutations through the use of interspecific genetic variation.

@article{Miller2001UnderstandingHD,
  title={Understanding human disease mutations through the use of interspecific genetic variation.},
  author={Mark P Miller and Shashvita Kumar},
  journal={Human molecular genetics},
  year={2001},
  volume={10 21},
  pages={2319-28}
}
Data on replacement mutations in genes of disease patients exist in a variety of online resources. In addition, genome sequencing projects and individual gene sequencing efforts have led to the identification of disease gene homologs in diverse metazoan species. The availability of these two types of information provides unique opportunities to investigate factors that are important in the development of genetically based disease by contrasting long and short-term molecular evolutionary… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 38 references

Cystic Fibrosis

M. J. Welsh, B. W. Ramsey, F. Accurso, G. R. Cutting
McGraw-Hill, New York, • 2000

Human mutations in glucose 6-phosphate dehydrogenase reflect evolutionary history.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2000

Mutation databases: overview and catalogues

R. Horaitis, C. R. Scriver, R.G.H. Cotton
McGraw-Hill, New York, • 2000

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