Understanding how the distal environment directs reactivity in chlorite dismutase: spectroscopy and reactivity of Arg183 mutants.

@article{Blanc2012UnderstandingHT,
  title={Understanding how the distal environment directs reactivity in chlorite dismutase: spectroscopy and reactivity of Arg183 mutants.},
  author={Beatrice Guilhon Blanc and Jeffery A. Mayfield and Claudia Alejandra McDonald and Gudrun S Lukat-Rodgers and Kenton R. Rodgers and Jennifer L DuBois},
  journal={Biochemistry},
  year={2012},
  volume={51 9},
  pages={
          1895-910
        }
}
The chlorite dismutase from Dechloromonas aromatica (DaCld) catalyzes the highly efficient decomposition of chlorite to O(2) and chloride. Spectroscopic, equilibrium thermodynamic, and kinetic measurements have indicated that Cld has two pH sensitive moieties; one is the heme, and Arg183 in the distal heme pocket has been hypothesized to be the second. This active site residue has been examined by site-directed mutagenesis to understand the roles of positive charge and hydrogen bonding in O-O… CONTINUE READING
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