Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals

  title={Understanding how stress responses and stress-related behaviors have evolved in zebrafish and mammals},
  author={Murilo S. de Abreu and Konstantin A. Demin and Ana C.V.V. Giacomini and Tamara G. Amstislavskaya and Tatyana Strekalova and Gleb O. Maslov and Yury Kositsin and Elena V Petersen and Allan V. Kalueff},
  journal={Neurobiology of Stress},

Figures and Tables from this paper

Relaxin ligand/receptor systems in the developing teleost fish brain: Conserved features with mammals and a platform to address neuropeptide system functions

The relaxins (RLNs) are a group of peptide hormone/neuromodulators that can regulate a wide range of physiological processes ranging from reproduction to brain function. All the family members have

Characterization of neurobehavioral pattern in a zebrafish 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model: A 96-hour behavioral study

Parkinson’s disease (PD) is the most common brain motor disorder, characterized by a substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Motor impairments, such as

Optogenetic induction of chronic glucocorticoid exposure in early-life impairs stress-response in larval zebrafish

It is proposed that this model can be leveraged to tease apart the mechanisms underlying developmental programming of HPA axis by early-life stress and its implications for vulnerability and resilience to stress in adulthood.

A Mini-Review Regarding the Modalities to Study Neurodevelopmental Disorders-Like Impairments in Zebrafish—Focussing on Neurobehavioural and Psychological Responses

The aim of this review is to describe and to argue the necessity of early developmental stages zebrafish models, focusing on NDDs, especially autism spectrum disorders (ASD) and also on schizophrenia.

Zebrafish, Medaka and Turquoise Killifish for Understanding Human Neurodegenerative/Neurodevelopmental Disorders

These small fishes are excellent animal models for the analysis of human neurological disorders and are expected to play increasing roles in this field.



Acute net stress of young adult zebrafish (Danio rerio) is not sufficient to increase anxiety-like behavior and whole-body cortisol

The results suggest the need for a different or more intense acute stressor in order to further explore neuroendocrine mechanisms and anxiety-like behavior at this developmental stage in the zebrafish animal model.

Experimental models of stress

The description of key features of models based on naturalistic stressors, pharmacological challenges, and genomic manipulations is complemented by comprehensive analysis of physiological, behavioral, neurochemical, and endocrine changes and their appropriatness as outcome readouts.

Thirty-Second Net Stressor Task in Adult Zebrafish.

A detailed protocol for a simple 30-sec net stressor task for adult zebrafish that increases whole-body cortisol levels without altering the levels of whole-brain dopamine, 3, 4-dihydroxyphenylacetic acid, serotonin, and 5-hydroxyindoleacetic Acid is provided.

Understanding neurobehavioral effects of acute and chronic stress in zebrafish

The zebrafish emerges as a powerful and sensitive model organism for stress research, being able to uniquely empower translational research of genetic determinants of stress and resilience, as well as to foster innovative CNS drug discovery and the development of novel anti-stress therapies.

No experimental evidence of stress-induced hyperthermia in zebrafish (Danio rerio)

It is suggested that zebrafish may not experience SIH, and claims regarding fish consciousness based on SIH may need to be revised, as no evidence was found for a stress-induced preference for warmer areas.

Housing Conditions Differentially Affect Physiological and Behavioural Stress Responses of Zebrafish, as well as the Response to Anxiolytics

It is demonstrated that housing represents an important factor in obtaining reliable data from this methodology, and should be considered by researchers interested in comparative models of anxiety in zebrafish in order to refine their approach and to increase the power in their experiments.

The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function

The case for using zebra fish as models to study impulse control and attention is outlined, discussing the validity of applying extant rodent assays to zebrafish and evidence for the conservation of relevant neural circuits.

Zebrafish as a Genetic Model in Biological and Behavioral Gerontology: Where Development Meets Aging in Vertebrates – A Mini-Review

It is suggested that the zebrafish genetic model offers a unique opportunity to fill in this gap in understanding the molecular mechanisms of aging and in developing preventive and therapeutic strategies to prolong the productive life span (‘health span’) in humans.

Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4

The findings demonstrate long-lasting stress-inducible changes in AChE's promoter choices, identify the chromatin changes that support this long-term transcriptional memory, and reveal HDAC4 as a mediator of these effects in the hippocampus.