Understanding how diverse beta-mannanases recognize heterogeneous substrates.

@article{Tailford2009UnderstandingHD,
  title={Understanding how diverse beta-mannanases recognize heterogeneous substrates.},
  author={Louise E. Tailford and Val{\'e}rie M.-A. Ducros and James E. Flint and Shirley M. Roberts and Carl Morland and David L Zechel and Nicola L. Smith and Mads Eskelund Bj{\o}rnvad and Torben Vedel Borchert and Keith S Wilson and Gideon J. Davies and Harry J. Gilbert},
  journal={Biochemistry},
  year={2009},
  volume={48 29},
  pages={
          7009-18
        }
}
The mechanism by which polysaccharide-hydrolyzing enzymes manifest specificity toward heterogeneous substrates, in which the sequence of sugars is variable, is unclear. An excellent example of such heterogeneity is provided by the plant structural polysaccharide glucomannan, which comprises a backbone of beta-1,4-linked glucose and mannose units. beta-Mannanases, located in glycoside hydrolase (GH) families 5 and 26, hydrolyze glucomannan by cleaving the glycosidic bond of mannosides at the -1… Expand
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