Understanding heterogeneity in grey matter research of adults with childhood maltreatment—A meta-analysis and review

  title={Understanding heterogeneity in grey matter research of adults with childhood maltreatment—A meta-analysis and review},
  author={Casey Paquola and Max R. Bennett and Jim Lagopoulos},
  journal={Neuroscience \& Biobehavioral Reviews},

Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study.

The results indicate that childhood trauma importantly contributes to the neurobiological changes commonly observed across psychiatric disorders, and frontal volume alterations may underpin affective and cognitive disturbances observed in trauma-exposed individuals.

Childhood maltreatment is associated with gray matter volume abnormalities in patients with first-episode depression

Hippocampal development in youth with a history of childhood maltreatment.

Structural and Functional Brain Abnormalities Associated With Exposure to Different Childhood Trauma Subtypes: A Systematic Review of Neuroimaging Findings

There is some evidence for long-term differential effects of trauma subtypes on the human brain following exposure to threatening life events, though promising, the current evidence is incomplete.

Machine Learning Analysis of the Relationships Between Gray Matter Volume and Childhood Trauma in a Transdiagnostic Community-Based Sample.

Childhood trauma and amygdala nuclei volumes in youth at risk for mental illness.

The experience of physical or sexual abuse may leave detectable structural alterations in key regions of the amygdala, potentially mediating the risk of psychopathology in trauma-exposed youth.

Examining the common and specific grey matter abnormalities in childhood maltreatment and peer victimisation

Background Early-life interpersonal stress, particularly childhood maltreatment, is associated with neurobiological abnormalities. However, few studies have investigated the neural effects of peer



Gray matter abnormalities in childhood maltreatment: a voxel-wise meta-analysis.

The findings demonstrate that the most consistent gray matter abnormalities in individuals exposed to childhood maltreatment are in relatively late-developing ventrolateral prefrontal-limbic-temporal regions that are known to mediate late-developmenting functions of affect and cognitive control, which are typically compromised in this population.

Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants.

The results suggest that early childhood maltreatment is associated with brain structural changes irrespective of sex, age and a history of depression, and highlights the importance of childhood malt treatment when investigating brain structures.

Hippocampal Atrophy in Major Depression: a Function of Childhood Maltreatment Rather than Diagnosis?

The results suggest that hippocampal alterations in MDD patients may at least partly be traced back to higher occurrence of early-life adverse experiences, which is an alternative explanation for frequently observed limbic structural abnormalities in depressed patients.

Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder.

The results support a dorsal prefrontal-striatal model of the disorder and raise the question of whether functional alterations in other brain regions commonly associated with OCD, such as the orbitofrontal cortex, may reflect secondary compensatory strategies.

Childhood trauma and hippocampal and amygdalar volumes in first-episode psychosis.

It is indicated that childhood trauma is associated with neuroanatomical measures in FEP, and controlling for childhood traumatic experiences may contribute to explaining brain morphology in people with psychosis.