Understanding eukaryotic linear motifs and their role in cell signaling and regulation.

  title={Understanding eukaryotic linear motifs and their role in cell signaling and regulation.},
  author={Francesca Diella and Niall J. Haslam and Claudia Chica and Aidan Budd and Sushama Michael and Nigel P. Brown and Gilles Trav{\'e} and Toby J. Gibson},
  journal={Frontiers in bioscience : a journal and virtual library},
It is now clear that a detailed picture of cell regulation requires a comprehensive understanding of the abundant short protein motifs through which signaling is channeled. The current body of knowledge has slowly accumulated through piecemeal experimental investigation of individual motifs in signaling. Computational methods contributed little to this process. A new generation of bioinformatics tools will aid the future investigation of motifs in regulatory proteins, and the disordered… 

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