Understanding drug ototoxicity: molecular insights for prevention and clinical management

@article{Yorgason2006UnderstandingDO,
  title={Understanding drug ototoxicity: molecular insights for prevention and clinical management},
  author={Joshua G. Yorgason and Jose N. Fayad and Federico Kalinec},
  journal={Expert Opinion on Drug Safety},
  year={2006},
  volume={5},
  pages={383 - 399}
}
Ototoxicity is a trait shared by aminoglycoside and macrolide antibiotics, loop diuretics, platinum-based chemotherapeutic agents, some NSAIDs and antimalarial medications. Because their benefits in combating certain life-threatening diseases often outweigh the risks, the use of these ototoxic drugs cannot simply be avoided. In this review, the authors discuss some of the most frequently used ototoxic drugs and what is currently known about the cell and molecular mechanisms underlying their… 

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