- GeologyEncyclopedia of Evolutionary Psychological Science
This study carries on the assessing of the productivity of fissured aquifers of the regions of Ouaddaï and Biltine from an approach which takes into account climate variability, water balance, the…
GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits
- BiologyNature Communications
This study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits and identifies 50 and 13 novel loci, respectively, some of which show a potential causal relationship with blood pressure based on MR analysis.
Serum uric acid levels in acute myocardial infarction
Serum uric acid levels are higher in patients of acute myocardial infarction as compared to normal healthy persons and combines with Killip class is a good predictor of mortality after acute my Cardiac Infarction.
Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout
- BiologyJournal of Human Genetics
Combined exposure to the four high-risk genotypes of ALPK1 and the uric-acid-related loci of ABCG2, SLC2A9, and SLC22A12 was associated with an increased gout risk and a high PPV for gout.
Investigation of Some Biochemical Parameters in Subject with HbSC and HbSS in Saki West Local Government - a Rural Community in Nigeria
Low plasma level of Selenium and increased plasma AST and ALT were found in HbSS and HbSC patients, while biochemical alterations including plasma Zn was more in crisis than in non-crisis steady state.
Physiological effect Of Selenium& Green treatment on Cisplatin-induced Nephrotoxicity in Rats
The results suggest that the use of selenium& green tea could be beneficial in improving kidney functions in nephrotoxic rats, through a significant decrease in peroxidative levels and increase in antioxidant status.
Additive composite ABCG2, SLC2A9 and SLC22A12 scores of high-risk alleles with alcohol use modulate gout risk
- MedicineJournal of Human Genetics
The synergistic effect of genetic urate score 5–6 and alcohol use indicates that these combined factors correlate with gout and tophi occurrence.
THE ROLE OF URIC ACID IN IMPAIRMENT OF THE GLOMERULAR FILTERATION RATE IN NONPROTEINURIC PATIENTS WITH TYPE 2 DIABETES MELLITUS
Measurement of serum uric acid, HBA1c, total cholesterol and C-reactive protein and their relationship to the estimated GFR by using Cockcroft – Gault formula found increased uric Acid levels were associated with increased risk of development of hypertension, cardiovascular disease and progression of chronic kidney disease.
Gout and Hyperuricemia
Strength of secretory and absorptive urate transporter genes in gout arthritis
- Medicine, Biology
The GWAS discovery of urate transporter genes in the ABCG2, SLC2A9 and SLC22A12 causing gout adds considerably to the understanding of the pathogenesis of gout and may facilitate risk communication between patients and clinicians.
SHOWING 1-10 OF 10 REFERENCES
Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout.
- Medicine, BiologyArthritis and rheumatism
Infusing 4-12 mg of PEG-uricase every 2-4 weeks should maintain the pUAc well below the therapeutic target of 6 mg/dl and greatly reduce renal uric acid excretion, which could be effective in depleting expanded tissue urate stores in patients with chronic or tophaceous gout.
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
- MedicineThe Lancet
Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout.
- MedicineArthritis and rheumatism
Treatment with febuxostat resulted in a significant reduction of sUA levels at all dosages and was safe and well tolerated.
Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population.
- BiologyArthritis and rheumatism
OBJECTIVE Human urate transporter 1 (hURAT1) is a member of the organic anion transporter family (SLC22A12) that mainly regulates tubular urate reabsorption. Loss-of-function mutations result in…
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
- Biology, MedicineAmerican journal of human genetics
Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
- Biology, MedicineNature
This work identifies the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricOSuric agents (which affect excretion of uric acid).
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
- MedicineNature Genetics
Analysis of whole blood RNA expression profiles from a KORA F3 500K subgroup showed a significant association between the SLC2A9 isoform 2 and urate concentrations and the S LC2A 9 genotypes also showed significant association with self-reported gout.
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
- Biology, MedicineNature Genetics
Genetic variants within a transporter gene, SLC2A9, that explain 1.7–5.3% of the variance in serum uric acid concentrations are identified following a genome-wide association scan in a Croatian population sample and it is shown that it has strong uric Acid transport activity in Xenopus laevis oocytes.
EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee For International Clinical Studies Including Therapeutics (ESCISIT)
- MedicineAnnals of the rheumatic diseases
12 key recommendations for management of gout were developed, using a combination of research based evidence and expert consensus, based on a Delphi consensus approach.
Gout-associated uric acid crystals activate the NALP3 inflammasome
- Biology, MedicineNature
It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.