Understanding deficient elimination of uric acid

@article{Aringer2008UnderstandingDE,
  title={Understanding deficient elimination of uric acid},
  author={Martin Aringer and Juergen Graessler},
  journal={The Lancet},
  year={2008},
  volume={372},
  pages={1929-1930}
}
Researcher
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References

SHOWING 1-10 OF 10 REFERENCES
Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout.
TLDR
Infusing 4-12 mg of PEG-uricase every 2-4 weeks should maintain the pUAc well below the therapeutic target of 6 mg/dl and greatly reduce renal uric acid excretion, which could be effective in depleting expanded tissue urate stores in patients with chronic or tophaceous gout.
Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout.
TLDR
Treatment with febuxostat resulted in a significant reduction of sUA levels at all dosages and was safe and well tolerated.
Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population.
OBJECTIVE Human urate transporter 1 (hURAT1) is a member of the organic anion transporter family (SLC22A12) that mainly regulates tubular urate reabsorption. Loss-of-function mutations result in
Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
TLDR
This work identifies the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricOSuric agents (which affect excretion of uric acid).
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
TLDR
Analysis of whole blood RNA expression profiles from a KORA F3 500K subgroup showed a significant association between the SLC2A9 isoform 2 and urate concentrations and the S LC2A 9 genotypes also showed significant association with self-reported gout.
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
TLDR
Genetic variants within a transporter gene, SLC2A9, that explain 1.7–5.3% of the variance in serum uric acid concentrations are identified following a genome-wide association scan in a Croatian population sample and it is shown that it has strong uric Acid transport activity in Xenopus laevis oocytes.
EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee For International Clinical Studies Including Therapeutics (ESCISIT)
TLDR
12 key recommendations for management of gout were developed, using a combination of research based evidence and expert consensus, based on a Delphi consensus approach.
Gout-associated uric acid crystals activate the NALP3 inflammasome
TLDR
It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.