Understanding clinical signs of poor tissue perfusion during septic shock

  title={Understanding clinical signs of poor tissue perfusion during septic shock},
  author={Hafid Ait-Oufella and Jan Bakker},
  journal={Intensive Care Medicine},
Acute circulatory failure associated with infection, referred to as septic shock, is characterized by an inadequate tissue perfusion and oxygenation relative to metabolic requirements. This imbalance between delivery and tissue uptake is mainly due to altered microvascular blood flow regulation as a result of dysregulated and/ or injured endothelial cells. Endothelial dysfunction is presumably induced by pathogenic bacterial products, inflammatory mediators, and reactive oxygen species produced… CONTINUE READING
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