Understanding cell death in Parkinson's disease.

  title={Understanding cell death in Parkinson's disease.},
  author={Peter Jenner and Charles W. Olanow},
  journal={Annals of neurology},
  volume={44 3 Suppl 1},
Current concepts of the cause of Parkinson's disease (PD) suggest a role for both genetic and environmental influences. Common to a variety of potential causes of nigral cell degeneration in PD is the involvement of oxidative stress. Postmortem analysis shows increased levels of iron, decreased complex I activity, and a decrease in reduced glutathione (GSH) levels. The decrease in GSH levels may be a particularly important component of the cascade of events leading to cell death because it… CONTINUE READING
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