Understanding breast cancer stem cell heterogeneity: time to move on to a new research paradigm

@inproceedings{Mannello2013UnderstandingBC,
  title={Understanding breast cancer stem cell heterogeneity: time to move on to a new research paradigm},
  author={Ferdinando Mannello},
  booktitle={BMC medicine},
  year={2013}
}
Human breast cancer (BC) is one of the leading causes of death for women worldwide, and is characterized by a group of highly heterogeneous lesions. The morphological and biomolecular heterogeneity of BC cells, accompanied by dynamic plasticity of the BC microenvironment and the presence of stem-like cells, make tumor categorization an urgent and demanding task.The major limitations in BC research include the high flexibility rate of breast cancer stem cells (BCSCs) and the difficulty of their… CONTINUE READING
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