Understanding breast cancer stem cell heterogeneity: time to move on to a new research paradigm

  title={Understanding breast cancer stem cell heterogeneity: time to move on to a new research paradigm},
  author={Ferdinando Mannello},
  booktitle={BMC medicine},
Human breast cancer (BC) is one of the leading causes of death for women worldwide, and is characterized by a group of highly heterogeneous lesions. The morphological and biomolecular heterogeneity of BC cells, accompanied by dynamic plasticity of the BC microenvironment and the presence of stem-like cells, make tumor categorization an urgent and demanding task.The major limitations in BC research include the high flexibility rate of breast cancer stem cells (BCSCs) and the difficulty of their… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 14 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 22 extracted citations


Publications referenced by this paper.
Showing 1-10 of 23 references

Profiling of normal and malignant breast tissues show CD 44 high / CD 24 low phenotype as a predominant stem / progenitor marker when used in combination with EpCAM / CD 49 f markers

  • H Ghebeh
  • BMC Cancer
  • 2013

Cancer stem cell definitions and terminology: the devil is in the details

  • P Valent, D Bonnet, +7 authors G Stassi
  • Nat Rev Cancer
  • 2012
1 Excerpt

Similar Papers

Loading similar papers…