Understanding bipolar disorder: the epigenetic perspective.

  title={Understanding bipolar disorder: the epigenetic perspective.},
  author={Tarang Khare and Mrinal Pal and Artūras Petronis},
  journal={Current topics in behavioral neurosciences},
Bipolar disease (BPD) is a complex major psychiatric disorder that affects between 1% and 2% of the population and exhibits ?85% heritability. This has made BPD an appealing target for genetic studies yet, despite numerous attempts, the genetic basis of this disease remains elusive. Recently, it has come to light that epigenetic factors may also influence the development of BPD. These factors act via stable but reversible modifications of DNA and chromatin structure. In this chapter, we revisit… CONTINUE READING