Understanding biophysicochemical interactions at the nano-bio interface.

@article{Nel2009UnderstandingBI,
  title={Understanding biophysicochemical interactions at the nano-bio interface.},
  author={Andre E. Nel and Lutz M{\"a}dler and Darrell Velegol and Tian Xia and Eric M. V. Hoek and P. Somasundaran and Frederick C Klaessig and Vincent Castranova and Michael Thompson},
  journal={Nature materials},
  year={2009},
  volume={8 7},
  pages={
          543-57
        }
}
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could… 
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References

SHOWING 1-10 OF 100 REFERENCES
Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
TLDR
The rates of protein association and dissociation are determined using surface plasmon resonance technology with nanoparticles that are thiol-linked to gold, and through size exclusion chromatography of protein–nanoparticle mixtures, and this method is developed into a systematic methodology to isolate nanoparticle-associated proteins.
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
TLDR
The long-lived (“hard”) protein corona formed from human plasma is studied for a range of nanoparticles that differ in surface properties and size and both size and surface properties were found to play a very significant role.
Cell-directed assembly of bio/nano interfaces-a new scheme for cell immobilization.
TLDR
This work shows this interface to form by an active interplay between the living cell and surrounding matrix, which it refers to as cell-directed assembly (CDA).
Adsorbed proteins influence the biological activity and molecular targeting of nanomaterials.
TLDR
Investigation of nanomaterial uptake or toxicity in the RAW 264.7 macrophage-like model suggests an important role for adsorbed proteins in modulating the uptake and toxicity of SWCNTs and nano-sized amorphous silica.
Toxic Potential of Materials at the Nanolevel
TLDR
The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
The role of interparticle and external forces in nanoparticle assembly.
TLDR
Why and how a combination of self- and directed-assembly processes, involving interparticle and externally applied forces, can be applied to produce desired nanostructured materials are discussed.
Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm.
TLDR
It is demonstrated that ROS generation and oxidative stress are a valid test paradigm to compare NP toxicity, and particle interactions with cellular components are capable of generating oxidative stress.
Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles.
TLDR
It is shown that the former particles penetrate the plasma membrane without bilayer disruption, whereas the latter are mostly trapped in endosomes, offering a paradigm for analysing the fundamental problem of cell-membrane-penetrating bio- and macro-molecules.
Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells.
TLDR
Results indicate that gold nanorods are well suited for therapeutic applications, such as thermal cancer therapy, due to their tunable cell uptake and low toxicity.
The effect of particle design on cellular internalization pathways
TLDR
These findings suggest that HeLa cells readily internalize nonspherical particles with dimensions as large as 3 μm by using several different mechanisms of endocytosis, and it was found that rod-like particles enjoy an appreciable advantage when it comes to internalization rates.
...
...