Understanding bilirubin conformation and binding. Circular dichroism of human serum albumin complexes with bilirubin and its esters.

@article{Lighnter1988UnderstandingBC,
  title={Understanding bilirubin conformation and binding. Circular dichroism of human serum albumin complexes with bilirubin and its esters.},
  author={D A Lighnter and W. M. K. P. Wijekoon and Massimo F. Bertino'Jared F. Hund'Guohui Zhang},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 32},
  pages={16669-76}
}
Human serum albumin binds tightly and noncovalently to a wide variety of hydrophobic bilirubins, including (4Z,15Z)-bilirubin-IX alpha, its dimethyl ester and mono methyl esters, its mono 2-butyl esters and amides, the dimethyl ester of (4Z,15Z)-mesobilirubin-IV alpha, and even (4Z,15Z)-etiobilirubin-IV gamma. The heteroassociation complexes formed from these highly water-insoluble pigments and the protein can be prepared in pH 7.4 aqueous by using a small quantity of dimethyl sulfoxide as… CONTINUE READING