Understanding autophagy in cell death control.

  title={Understanding autophagy in cell death control.},
  author={Francesca Platini and Ricardo P{\'e}rez-T{\'o}mas and Santiago Ambrosio and Luciana Tessitore},
  journal={Current pharmaceutical design},
  volume={16 1},
Autophagy is an evolutionarily conserved degradation pathway which primary functions as a cell survival adaptive mechanism during stress conditions. Autophagy is a tumor suppressor process and induction of the autophagic machinery can cause cell demise in apoptosis-resistant cancer. Thus, this metabolic pathway can act either to prevent or to promote carcinogenesis, as well as to modulate the response to anticancer therapies, included drug-induced apoptosis. Conventional therapies exert their… CONTINUE READING
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