Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis.

@article{Urdahl2014UnderstandingAO,
  title={Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis.},
  author={Kevin B. Urdahl},
  journal={Seminars in immunology},
  year={2014},
  volume={26 6},
  pages={578-87}
}
Despite the overwhelming success of immunization in reducing, and even eliminating, the global threats posed by a wide spectrum of infectious diseases, attempts to do the same for tuberculosis (TB) have failed to date. While most effective vaccines act by eliciting neutralizing antibodies, T cells are the primary mediators of adaptive immunity against TB. Unfortunately, the onset of the T cell response after aerosol infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes TB… CONTINUE READING
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