Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation.

Abstract

Opalescence and high viscosities can pose challenges for high concentration formulation of antibodies. Both phenomena result from protein-protein intermolecular interactions that can be modulated with solution ionic strength. We studied a therapeutic monoclonal antibody (mAb) that exhibits high viscosity in solutions at low ionic strength ( approximately 20… (More)
DOI: 10.1002/jps.21797

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