Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation.


Opalescence and high viscosities can pose challenges for high concentration formulation of antibodies. Both phenomena result from protein-protein intermolecular interactions that can be modulated with solution ionic strength. We studied a therapeutic monoclonal antibody (mAb) that exhibits high viscosity in solutions at low ionic strength ( approximately 20… (More)
DOI: 10.1002/jps.21797


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics