Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.

@article{Thorson2000UnderstandingAE,
  title={Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.},
  author={Jon S Thorson and Eric L. Sievers and Joachim Ahlert and Erica Shepard and Ross E Whitwam and Kenolisa C Onwueme and Mark E Ruppen},
  journal={Current pharmaceutical design},
  year={2000},
  volume={6 18},
  pages={
          1841-79
        }
}
The enediyne antitumor antibiotics are appreciated for their novel molecular architecture, their remarkable biological activity and their fascinating mode of action and many have spawned considerable interest as anticancer agents in the pharmaceutical industry. Of equal importance to these astonishing properties, the enediynes also offer a distinct opportunity to study the unparalleled biosyntheses of their unique molecular scaffolds and what promises to be unprecedented modes of self… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Novel approaches to pediatric leukemia treatment.

Expert review of anticancer therapy • 2015
View 1 Excerpt

Agents for refractory/relapsed acute lymphocytic leukemia in adults.

European review for medical and pharmacological sciences • 2014

Novel antibody therapy in acute lymphoblastic leukemia.

Current hematologic malignancy reports • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…