Understanding and Sensitizing Density-Dependent Persistence to Quinolone Antibiotics.

  title={Understanding and Sensitizing Density-Dependent Persistence to Quinolone Antibiotics.},
  author={Arnaud Gutierrez and Saloni R. Jain and Prerna Bhargava and Meagan Hamblin and Michael A. Lobritz and James J. Collins},
  journal={Molecular cell},
  volume={68 6},
Physiologic and environmental factors can modulate antibiotic activity and thus pose a significant challenge to antibiotic treatment. The quinolone class of antibiotics, which targets bacterial topoisomerases, fails to kill bacteria that have grown to high density; however, the mechanistic basis for this persistence is unclear. Here, we show that exhaustion of the metabolic inputs that couple carbon catabolism to oxidative phosphorylation is a primary cause of growth phase-dependent persistence… CONTINUE READING
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