Understanding amyloid aggregation by statistical analysis of atomic force microscopy images.

@article{Adamcik2010UnderstandingAA,
  title={Understanding amyloid aggregation by statistical analysis of atomic force microscopy images.},
  author={Jozef Adamcik and Jin-Mi Jung and J{\'e}r{\^o}me Flakowski and Paolo De Los Rios and Giovanni Dietler and Raffaele Mezzenga},
  journal={Nature nanotechnology},
  year={2010},
  volume={5 6},
  pages={423-8}
}
The aggregation of proteins is central to many aspects of daily life, including food processing, blood coagulation, eye cataract formation disease and prion-related neurodegenerative infections. However, the physical mechanisms responsible for amyloidosis-the irreversible fibril formation of various proteins that is linked to disorders such as Alzheimer's, Creutzfeldt-Jakob and Huntington's diseases-have not yet been fully elucidated. Here, we show that different stages of amyloid aggregation… CONTINUE READING

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