Understanding alternative splicing: towards a cellular code

  title={Understanding alternative splicing: towards a cellular code},
  author={Arianne J. Matlin and Francis Clark and Christopher W. J. Smith},
  journal={Nature Reviews Molecular Cell Biology},
In violation of the 'one gene, one polypeptide' rule, alternative splicing allows individual genes to produce multiple protein isoforms — thereby playing a central part in generating complex proteomes. Alternative splicing also has a largely hidden function in quantitative gene control, by targeting RNAs for nonsense-mediated decay. Traditional gene-by-gene investigations of alternative splicing mechanisms are now being complemented by global approaches. These promise to reveal details of the… CONTINUE READING
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