Understanding Why Probiotic Therapies Can be Effective in Treating IBD

@article{Fedorak2008UnderstandingWP,
  title={Understanding Why Probiotic Therapies Can be Effective in Treating IBD},
  author={Richard N Fedorak},
  journal={Journal of Clinical Gastroenterology},
  year={2008},
  volume={42},
  pages={S111-S115}
}
  • R. Fedorak
  • Published 1 September 2008
  • Medicine, Biology
  • Journal of Clinical Gastroenterology
Probiotics, for the treatment of inflammatory bowel disease, are a group of specific nonpathogenic bacteria that are functionally and genetically defined by their ability to reduce inflammation in the intestine. Although probiotics also seem to have broad beneficial effects in humans, both as a food and as a therapeutic agent, there are specific identified mechanisms in some, but not all, of these bacteria that are important relative to the pathogenesis of inflammatory bowel disease. Recently… 

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References

SHOWING 1-10 OF 51 REFERENCES

Probiotics in inflammatory bowel disease--therapeutic rationale and role.

  • F. Shanahan
  • Medicine, Biology
    Advanced drug delivery reviews
  • 2004

Mechanisms of Action of Probiotics in Intestinal Diseases

Scientally accredited evidence of efficacy and studies to elucidate the molecular mechanisms of host-microbiota interactions are needed to lend credence to the use of pharmabiotic strategies in clinical medicine.

Antibiotics and probiotics in inflammatory bowel disease

Moderation therapy in ulcerative colitis and prevention therapy, as well as the treatment of pouchitis, have emerged as areas in which probiotic therapy offers a valid therapeutic alternative to current treatments, and further investigations may detect additional clinically effective probiotics and other clinical indications.

Probiotics and prebiotics in chronic inflammatory bowel diseases.

An overview of the role of the commensal microflora in maintaining mucosal immune homeostasis, and how a dysregulated immune response to the intestinalmicroflora results in IBD is presented.

A Key Role of Dendritic Cells in Probiotic Functionality

These results suggest that selected probiotics can stimulate DC regulatory functions by targeting specific pattern-recognition receptors and pathways, and indicate a possible role in immune-intervention therapy for IBD.

Probiotics as functional food in the treatment of diarrhea

  • Fang YanD. Polk
  • Medicine, Biology
    Current opinion in clinical nutrition and metabolic care
  • 2006
Growing evidence suggests that probiotics may serve as a functional food in the treatment of diarrhea and the correct combination and concentration of probiotics applied to the appropriate gastrointestinal disorders may improve the efficacy of this approach for diarrhea and other diseases.

Probiotics and intestinal health effects: a clinical perspective

The evidence for the efficacy of specific probiotic strains in human gastrointestinal diseases is critically analysed and the recent randomised controlled trials performed in patients with Clostridium difficile or Helicobacter pylori, inflammatory bowel disease, irritable bowel syndrome, non-ulcer dyspepsia and colon cancer are analysed.

Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date

  • E. QuigleyB. Flourié
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2007
The clear delineation of a post‐infective variety of irritable bowel syndrome (IBS), as well as the description, in a number of studies, of evidence of low‐grade inflammation and immune activation in IBS, suggest a role for a dysfunctional relationship between the indigenous flora and the host in Ibs and provide a clear rationale for the use of probiotics in this disorder.

Probiotic bacteria enhance murine and human intestinal epithelial barrier function.

In vitro studies showed that epithelial barrier function and resistance to Salmonella invasion could be enhanced by exposure to a proteinaceous soluble factor secreted by the bacteria found in the VSL#3 compound.

Modulation of human dendritic cell phenotype and function by probiotic bacteria

Probiotic bacteria differ in their immunomodulatory activity and influence polarisation of immune responses at the earliest stage of antigen presentation by dendritic cells.
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