Understanding Variation in Sets of N-of-1 Trials


A recent paper in this journal by Chen and Chen has used computer simulations to examine a number of approaches to analysing sets of n-of-1 trials. We have examined such designs using a more theoretical approach based on considering the purpose of analysis and the structure as regards randomisation that the design uses. We show that different purposes… (More)
DOI: 10.1371/journal.pone.0167167

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