Understanding TERT Promoter Mutations: A Common Path to Immortality.

Abstract

Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless proliferation driven by oncogenes. The recently discovered, highly recurrent mutations in the promoter of TERT are found in over 50 cancer types, and are the most common mutation in… (More)
DOI: 10.1158/1541-7786.MCR-16-0003

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