Understanding Parkinsonian Handwriting Through a Computational Model of Basal Ganglia

@article{Gangadhar2008UnderstandingPH,
  title={Understanding Parkinsonian Handwriting Through a Computational Model of Basal Ganglia},
  author={Garipelli Gangadhar and Denny Joseph and V. Srinivasa Chakravarthy},
  journal={Neural Computation},
  year={2008},
  volume={20},
  pages={2491-2525}
}
Handwriting in Parkinson's disease (PD) is typically characterized by micrographia, jagged line contour, and unusual fluctuations in pen tip velocity. Although PD handwriting features have been used for diagnostics, they are not based on a signaling model of basal ganglia (BG). In this letter, we present a computational model of handwriting generation that highlights the role of BG. When PD conditions like reduced dopamine and altered dynamics of the subthalamic nucleus and globus pallidus… CONTINUE READING
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