Understanding Mixed Sequence DNA Recognition by Novel Designed Compounds: The Kinetic and Thermodynamic Behavior of Azabenzimidazole Diamidines

@inproceedings{Paul2015UnderstandingMS,
  title={Understanding Mixed Sequence DNA Recognition by Novel
Designed Compounds: The Kinetic and Thermodynamic Behavior of Azabenzimidazole
Diamidines},
  author={Ananya Paul and Yun Chai and David W Boykin and W. D. Wilson},
  booktitle={Biochemistry},
  year={2015}
}
Sequence-specific recognition of DNA by small organic molecules offers a potentially effective approach for the external regulation of gene expression and is an important goal in cell biochemistry. Rational design of compounds from established modules can potentially yield compounds that bind strongly and selectively with specific DNA sequences. An initial approach is to start with common A·T bp recognition molecules and build in G·C recognition units. Here we report on the DNA interaction of a… CONTINUE READING
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