Understanding Human-Plasmodium falciparum Immune Interactions Uncovers the Immunological Role of Worms

@inproceedings{Roussilhon2010UnderstandingHF,
  title={Understanding Human-Plasmodium falciparum Immune Interactions Uncovers the Immunological Role of Worms},
  author={Christian Roussilhon and Philippe Brasseur and Patrice Agnamey and Jean-Louis P{\'e}rignon and Pierre L Druilhe},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Former studies have pointed to a monocyte-dependent effect of antibodies in protection against malaria and thereby to cytophilic antibodies IgG1 and IgG3, which trigger monocyte receptors. Field investigations have further documented that a switch from non-cytophilic to cytophilic classes of antimalarial antibodies was associated with protection. The hypothesis that the non-cytophilic isotype imbalance could be related to concomittant helminthic infections was supported by several… CONTINUE READING

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