Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure.

@article{Leoni2016UnderstandingGF,
  title={Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure.},
  author={Chiara Leoni and Roberta Onesimo and Valentina Giorgio and Antonella Diamanti and Daniela Giorgio and Lucilla Martini and Aurora Natalia Rossodivita and M Tartaglia and Giuseppe Zampino},
  journal={The Journal of pediatrics},
  year={2016},
  volume={170},
  pages={322-4}
}
Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive. 

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