Understanding Equivalence and Noninferiority Testing

@article{Walker2010UnderstandingEA,
  title={Understanding Equivalence and Noninferiority Testing},
  author={Esteban Walker and Amy S. Nowacki},
  journal={Journal of General Internal Medicine},
  year={2010},
  volume={26},
  pages={192-196}
}
Increasingly, the goal of many studies is to determine if new therapies have equivalent or noninferior efficacies to the ones currently in use. These studies are called equivalence/noninferiority studies, and the statistical methods for their analysis require only simple modifications to the traditional hypotheses testing framework. Nevertheless, important and subtle issues arise with the application of such methods. This article describes the concepts and statistical methods involved in… CONTINUE READING
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