Understanding Compression-Induced Amorphization of Crystalline Posaconazole.

  title={Understanding Compression-Induced Amorphization of Crystalline Posaconazole.},
  author={Chengbin Huang and Gerard R. Klinzing and Adam Procopio and Fengyuan Yang and Jie Ren and Rubi Burlage and Lei Zhu and Yongchao Su},
  journal={Molecular pharmaceutics},
  volume={16 2},
Process-induced phase transformations (PIPTs) of active pharmaceutical ingredients (APIs) can alter APIs' physicochemical properties and impact performance of pharmaceutical drug products. In this study, we investigated compression-induced amorphization of crystalline posaconazole (POSA), where the impact of mechanical stresses and excipients on amorphization were explored. 19F solid-state NMR (ssNMR) was utilized to detect and quantify amorphous content in the compressed tablets, and finite… Expand
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