Understanding Caffeine's Role in Attenuating the Toxicity of α-Synuclein Aggregates: Implications for Risk of Parkinson's Disease.

@article{Kardani2015UnderstandingCR,
  title={Understanding Caffeine's Role in Attenuating the Toxicity of α-Synuclein Aggregates: Implications for Risk of Parkinson's Disease.},
  author={Jay R Kardani and Ipsita Roy},
  journal={ACS chemical neuroscience},
  year={2015},
  volume={6 9},
  pages={1613-25}
}
Epidemiological studies report a beneficial relationship between drinking coffee and the risk of developing Parkinson's disease (PD). This is likely due to caffeine, a constituent of coffee, acting as an adenosine A2A receptor antagonist. This study was planned to investigate whether caffeine has any effect on the aggregation of α-synuclein, present in Lewy… CONTINUE READING