Undermining ribosomal RNA transcription in both the nucleolus and mitochondrion: an offbeat approach to target MYC-driven cancer

@inproceedings{Rossetti2018UnderminingRR,
  title={Undermining ribosomal RNA transcription in both the nucleolus and mitochondrion: an offbeat approach to target MYC-driven cancer},
  author={Stefano Rossetti and Andrzej J. Wierzbicki and Nicoletta Sacchi},
  booktitle={Oncotarget},
  year={2018}
}
The MYC transcription factor coordinates, via different RNA polymerases, the transcription of both ribosomal RNA (rRNA) and protein genes necessary for nucleolar as well as mitochondrial ribogenesis. In this study we tested if MYC-coordination of rRNA transcription in the nucleolus and in the mitochondrion drives (cancer) cell proliferation. Here we show… CONTINUE READING