Underlying role of mitochondrial mutagenesis in the pathogenesis of a disease and current approaches for translational research

  title={Underlying role of mitochondrial mutagenesis in the pathogenesis of a disease and current approaches for translational research},
  author={Maria Paraskevaidi and Pierre P L Martin-Hirsch and Maria Kyrgiou and Francis L. Martin},
Mitochondrial diseases have been extensively investigated over the last three decades, but many questions regarding their underlying aetiologies remain unanswered. Mitochondrial dysfunction is not only responsible for a range of neurological and myopathy diseases but also considered pivotal in a broader spectrum of common diseases such as epilepsy, autism and bipolar disorder. These disorders are a challenge to diagnose and treat, as their aetiology might be multifactorial. In this review, the… Expand
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