Underlying mechanism of ASIC1a involved in acidosis-induced cytotoxicity in rat C6 glioma cells

@article{Weng2007UnderlyingMO,
  title={Underlying mechanism of ASIC1a involved in acidosis-induced cytotoxicity in rat C6 glioma cells},
  author={Xie-chuan Weng and Jian-quan Zheng and Jin Li and Wen-bin Xiao},
  journal={Acta Pharmacologica Sinica},
  year={2007},
  volume={28},
  pages={1731-1736}
}
AbstractAim:To investigate the underlying mechanism of acid-sensing ion channel (ASIC) 1a involved in the acidosis-induced cytotoxicity of rat C6 glioma cells.Methods:The stable ASIC1a-silenced C6 cells built with the RNA interference technology were confirmed by RT-PCR and Western blot analysis. Intracellular calcium ([Ca2+]i) in both the wild-type rat C6 glioma cells and the ASIC1a-silenced C6 cells were analyzed before and after acid application/exposure with the calcium imaging experiment… CONTINUE READING

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