Underexpression of messenger RNA for peripheral myelin protein 22 in hereditary neuropathy with liability to pressure palsies.

@article{Schenone1997UnderexpressionOM,
  title={Underexpression of messenger RNA for peripheral myelin protein 22 in hereditary neuropathy with liability to pressure palsies.},
  author={Angelo E Schenone and Lucilla Alessandra Nobbio and Paola Mandich and Emilia Bellone and M. D. James Abbruzzese and Felix Aymar and Giovanni Luigi Mancardi and Anthony J Windebank},
  journal={Neurology},
  year={1997},
  volume={48 2},
  pages={
          445-9
        }
}
Hereditary neuropathy with liability to pressure palsies (HNPP) is associated with a deletion in chromosome 17p11.2, including the gene for the peripheral myelin protein 22 (PMP-22). Because of the proposal that a decreased dosage of the PMP-22 gene was the cause of HNPP, we evaluated sural nerves from eight patients with the 17p11.2 deletion and from five normal controls. The relative amount of PMP-22 mRNA was significantly lower in HNPP patients compared with normal controls (p < 0.02) using… CONTINUE READING
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