Underexcretory-type hyperuricemia, disproportionate to the reduced glomerular filtration rate, in two boys with mild proteinuria.

@article{Murakami1990UnderexcretorytypeHD,
  title={Underexcretory-type hyperuricemia, disproportionate to the reduced glomerular filtration rate, in two boys with mild proteinuria.},
  author={Tadashi Murakami and Hayato Kawakami and Kiyoshi Nakatsuka and Kazutaka Jojima and H Nohno and Hiroyuki Matsuzaki},
  journal={Nephron},
  year={1990},
  volume={56 4},
  pages={439-42}
}
Two unrelated boys with mild persistent proteinuria and underexcretory-type hyperuricemia of more than 9.0 mg/dl (535 mumols/l) are described. The proteinuria was detected at age 10 and 6 years, respectively. The fractional excretion of uric acid in both was low at 2-3%, when the creatinine clearance was decreased by about 50%. Tissue examination revealed focal interstitial fibrosis in both patients and medullary urate crystals in one patient in whom medullary tissue was obtained on biopsy. An… CONTINUE READING