Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies.

@article{Clarke2001UnderestimationOT,
  title={Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies.},
  author={Robert J. Clarke and Sarah Lewington and Ann Donald and Colin Johnston and Helga Refsum and Irene Stratton and Paul H Jacques and Monique M. B. Breteler and Rury Holman},
  journal={Journal of cardiovascular risk},
  year={2001},
  volume={8 6},
  pages={363-9}
}
BACKGROUND In epidemiological studies, within-person variability in plasma total homocysteine (tHcy) measurements may dilute the association of 'usual' levels of tHcy with risk of cardiovascular disease, referred to as 'regression dilution'. The aim of this report was to estimate the magnitude of regression dilution after varying intervals of follow-up. METHODS Regression dilution ratios (RDR) for tHcy were calculated using replicate tHcy measurements obtained after 3, 6 and 8 years from the… CONTINUE READING

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