Underdosing the antidote for acetaminophen.

@article{Anker1993UnderdosingTA,
  title={Underdosing the antidote for acetaminophen.},
  author={A L Anker and Martin J. Smilkstein},
  journal={JAMA},
  year={1993},
  volume={269 10},
  pages={
          1252-3
        }
}
To the Editor. —We would like to inform your readers of a disturbing pattern in the treatment of acetaminophen overdoses. The Oregon Poison Center serves a population of 2.5 million people and, like all poison centers, it frequently deals with acetaminophen overdoses. In the last 6 months we have noted three instances in which physicians treating patients with acetaminophen overdoses discontinued acetylcysteine therapy on the basis of serial acetaminophen assays and did not complete the… Expand

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TLDR
It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed. Expand
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TLDR
This 48-hour IV N-acetylcysteine treatment protocol is safe and effective antidotal therapy for acetaminophen overdose and is equal to 72-hour oral and 20-hour intravenous treatment protocols when started early and superior to the 20- hour IV regimen when treatment is delayed. Expand
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.
TLDR
Intravenous acetylcysteine was more effective than cysteamine and methionine and noticeably free of adverse effects and is the treatment of choice for paracetamol poisoning. Expand
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.
TLDR
Acetylcysteine is safe and effective in fulminant hepatic failure after paracetamol overdose, and rates of deterioration and recovery of liver function were similar in the two groups. Expand