Undercarboxylated osteocalcin reverts insulin resistance induced by endoplasmic reticulum stress in human umbilical vein endothelial cells

@inproceedings{Guo2017UndercarboxylatedOR,
  title={Undercarboxylated osteocalcin reverts insulin resistance induced by endoplasmic reticulum stress in human umbilical vein endothelial cells},
  author={Qinyue Guo and Huixia Li and Lin Xu and ShuFang Wu and Hongzhi Sun and Bo Zhou},
  booktitle={Scientific Reports},
  year={2017}
}
Osteocalcin has been considered to be an important regulator of energy metabolism in type 2 diabetes mellitus (T2DM). However, the mechanism underlying the involvement of uncarboxylated osteocalcin in the vascular complications of T2DM is not fully understood. In the present study, we analyzed the potential correlations between uncarboxylated osteocalcin and macro- or microangiopathic complications in subjects with T2DM and tested the impact of uncarboxylated osteocalcin on insulin resistance… CONTINUE READING
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