Underappreciated Roles of the Translocase of the Outer and Inner Mitochondrial Membrane Protein Complexes in Human Disease.

@article{Heinemeyer2019UnderappreciatedRO,
  title={Underappreciated Roles of the Translocase of the Outer and Inner Mitochondrial Membrane Protein Complexes in Human Disease.},
  author={Thea Heinemeyer and Monique Stemmet and S. Bardien and A. Neethling},
  journal={DNA and cell biology},
  year={2019},
  volume={38 1},
  pages={
          23-40
        }
}
Mitochondria are critical for cellular survival, and for their proper functioning, translocation of ∼1500 proteins across the mitochondrial membranes is required. The translocase of the outer (TOMM) and inner mitochondrial membrane (TIMM) complexes are major components of this translocation machinery. Through specific processes, preproteins and other molecules are imported, translocated, and directed to specific mitochondrial compartments for their function. In this study, we review the… Expand
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References

Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia
  • R. Cacabelos
  • Medicine
  • International journal of molecular sciences
  • 2020
TLDR
The incorporation of pharmacogenomic strategies for a personalized treatment in dementia is an effective option to optimize limited therapeutic resources and to reduce unwanted side-effects. Expand