Under the curve: Critical issues for elucidating D1 receptor function in working memory

@article{Williams2006UnderTC,
  title={Under the curve: Critical issues for elucidating D1 receptor function in working memory},
  author={G. V. Williams and Stacy A. Castner},
  journal={Neuroscience},
  year={2006},
  volume={139},
  pages={263-276}
}
It has been postulated that spatial working memory operates optimally within a limited range of dopamine transmission and D1 dopamine receptor signaling in prefrontal cortex. Insufficiency in prefrontal dopamine, as in aging, and excessive transmission, as in acute stress, lead to impairments in working memory that can be ameliorated by D1 receptor agonist and antagonist treatment, respectively. Iontophoretic investigations of dopamine's influence on the cellular mechanisms of working memory… Expand
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