Under-Dominance Constrains the Evolution of Negative Autoregulation in Diploids

Abstract

Regulatory networks have evolved to allow gene expression to rapidly track changes in the environment as well as to buffer perturbations and maintain cellular homeostasis in the absence of change. Theoretical work and empirical investigation in Escherichia coli have shown that negative autoregulation confers both rapid response times and reduced intrinsic… (More)
DOI: 10.1371/journal.pcbi.1002992

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